Analytical technique is a method that is used to determine a chemical or physical property of a chemical substance, chemical element, or mixture. There are a wide variety of techniques used for analysis, from simple weighing to advanced techniques using highly specialized instrumentation.

The development of the pharmaceuticals brought a revolution in human health. These pharmaceuticals would serve their intent only if they are free from impurities and are administered in an appropriate amount. To make drugs serve their purpose various chemical and instrumental methods were developed at regular intervals which are involved in the estimation of drugs. These pharmaceuticals may develop impurities at various stages of their development, transportation and storage which makes the pharmaceutical risky to be administered thus they must be detected and quantitated. For this analytical instrumentation and methods play an important role. This review highlights the role of the analytical instrumentation and the analytical methods in assessing the quality of the drugs.

With the growing popularity of the nanomedicine-based pharmaceutical market, active molecules from chemical and natural origin are encapsulated in various nanocarriers enhancing their therapeutic efficacy. Depending upon the fabricated functionality, cyclodextrin based nanosponges has become a potential vehicle to encapsulate the active molecules. To explore nanosponges-based delivery system in pharmacy, knowledge of the analytical tools that could significantly assess their quality parameters, has major role for researchers working in this field. Owing to understand their benefits and potential toxicity, characteristic features like safety, negligible toxicity, superior inclusion capability, marked swelling behaviour and biodegradability are the primarily basis for their use in drug delivery, drug targeting, tissue engineering and regenerative medicine. This review article focuses on the various aspects of analytical techniques applied for characterization of nanosponges, which may affect quality of these nanocarriers. Subsequently, the challenges for characterization of these systems have been especially emphasized. In addition, sincere efforts have been made to compile various analytical techniques for description and understanding of these nanostructures from existing literature. Recommendations and suggestions are also mentioned while selecting suitable analytic techniques to characterize the quality parameters of nanosponges.

Regards,

Hanna Marin

Managing Editor

Journal of analytical and bioanalytical techniques

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